Generalized pustular psoriasis (GPP), also known as von Zumbusch psoriasis, is a rare and serious condition characterized by severely itchy pustules covering large portions of the body. It may begin with large areas of reddened, painful skin. Pustules then cover the skin in a matter of hours. It is typically accompanied by fever, chills, rapid heart rate, and nausea.

“If pustular psoriasis involves your entire body, it can become life-threatening. The high degree of inflammation can lead to rapid temperature shifts, an increased risk of dehydration (which can lead to electrolyte imbalance), and increased risk of infection,” explains Peterson Pierre, M.D. of the Pierre Skin Care Institute in Westlake Village, California.

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